Genomics of Preconditioning

Genomics of preconditioning.

Brief episodes of ischemia can protect against subsequent damaging ischemic events; however, the molecular mechanisms responsible for protection are poorly understood. Identifying genes involved in this process could provide insight into cell survival and treatment of stroke. We developed a murine model of ischemic preconditioning and subsequent stroke and used gene expression profiling to iden...

Comparative genomics of human stem cell factor (SCF)

Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCB...

Exercise preconditioning: review

It is estimated that by 2035, more than 130 million adults will suffer from various types of cardiovascular diseases. Therefore, it is very important to know the pathogens of cardiac diseases and investigate new treatments. Also, despite continuous progress in diagnosis, patient education, and risk factor management, myocardial infarction (MI) remains one of the most common causes of morbidity,...

Genomics update Wine Genomics

Time course of normobaric hyperoxia preconditioning on NCX2, 3 expression

Introduction: The purpose of this study was to determine Na-Ca exchanger 2, 3 (NCX2, 3) protein level changes during 2, 5, 10, 15 days after induction of normobaric hyperoxia (HO) preconditioning. Materials and Methods: Rats were divided in two experimental groups. The first group was exposed to 95% inspired HO for 4 h/day for 6 consecutive days (HO). The second group acted as control, and was...